A rookie policewoman in New Orleans captures corrupt officers murdering a drug dealer on camera. She must soon go on the run when the perpetrators pursue her in a desperate attempt to destroy the footage.

Abandoned on the mean city streets by his lowlife owner, Doug, a naive but lovable dog named Reggie falls in with a fast-talking, foul-mouthed Boston Terrier and his gang of strays. Determined to seek revenge, Reggie and his new canine pals embark on an epic adventure to get him home and make Doug pay for his dirty deed.